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Safaa Hammoud

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Safaa Hammoud

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Pharmacology and Therapeutics Department

shamoud@bau.edu.lb

01 300110 Ex: 2361

Beirut

Safaa Hammoud

Assistant Professor of Pharmacology

Dr. Safaa Hammoud received her BSc degree in Pharmacy from Beirut Arab University in 2010 and a master's degree in Pharmacology in 2013. She was then granted a pre-doctoral scholarship from BAU/CNRS-L and proceeded to receive a Ph.D. degree in Pharmacology. 

Dr. Hammoud joined the faculty of pharmacy as a Lecturer in 2014 and was then promoted to Assistant Professor in 2018. She has previous experience for over 3 years as a hospital pharmacist and team leader.

Dr. Hammoud's research interest focuses on investigating the detrimental cardiac and renal influences of metabolic diseases and immunosuppressant drugs: molecular interplay along with central controlling mechanisms and potential therapeutic strategies. She has worked on several projects in the field of cardiovascular and renal systems as well as inflammation. Her work is regularly cited and recognized by international counterparts. The recent work on early renal abnormalities in metabolic diseases was recognized by the American Society of Pharmacology and Experimental Therapeutics and the American Heart Association.

Lately, she is working to highlight the cross-talk between SARS-CoV-2 pathogenesis pathways and cardiovascular disorders. Results from this project were published in three peer-reviewed journals and the work published in Molecular Pharmacology journal was selected as the Editor's Choice. 

Teaching

 

  • PHAR284 Biochemistry
  • PHAR 374 Pharmacotherapeutics I
  • PHAR 376 Integrated Case-Based Learning I 
  • PHAR 365 Fundamentals of Pharmacology 
  • PHAR 584 Pharmacology V 
  • PHAR 585 Pharmacotherapeutics VI 
  • PHAR 547 Pharmacology IV 
  • PHAR 571 Childhood disorders 
  • PHAR 580 Inter-Professional Education 
  • PHPT 710 Selected Topics in Pharmacology 
  • PHPT 717 Advanced Pharmaceutical Biochemistry 
  • PHPT 715 Pharmacogenetics and Pharmacogenomics 
.

 

Research

Published articles:

  • Hammoud, S. H., AlZaim, I., Al-Dhaheri, Y., Eid, A. H., and El-Yazbi, A. F. (2021). Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases. Front. Endocrinol. 12:707126.
    doi: 10.3389/fendo.2021.707126
  • Wehbe, Z.*, Hammoud, S. H. *, Yassine, H. M., Fardoun, M., El-Yazbi, A. F., Eid, A. H. (2021). Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality. Frontiers in Immunology. 2021;12.
  • Alaaeddine, R. A. *, AlZaim, I. *, Hammoud, S. H., Arakji, A., Eid, A. H., Abd-Elrahman, K. S., El-Yazbi, A. F. (2021). The pleiotropic effects of antithrombotic drugs in the metabolic-cardiovascular-neurodegenerative disease continuum: impact beyond reduced clotting. Clin Sci (Lond). 2021;135(8):1015-51.
  • Hammoud, S. H., Al Zaim., I., Mougharbil, N., Koubar, S., Eid, A. H., Eid, A. A., & El-Yazbi, A., F. (2021). Per-Renal adipose inflammation contributes to renal dysfunction in non-obese prediabetic rat model: Role of antidiabetic
    drugs. Biochem Pharmacolo, 186, 114491. doi:10.1016/j.bcp.2021.114491
  • Hammoud, S. H., AlZaim, I., Mougharbil, N., Koubar, S., Eid, A. H., Eid, A. A., & El-Yazbi, A. F. (2021). Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs. Biochem Pharmacol, 186, 114491. doi:10.1016/j.bcp.2021.114491
  • Hammoud, S. H., Wehbe, Z., Abdelhady, S., Kobeissy, F., Eid, A. H., & El-Yazbi, A. F. (2021). Dysregulation of Angiotensin Converting Enzyme 2 Expression and Function in Comorbid Disease Conditions Possibly Contributes to Coronavirus Infectious Disease 2019 Complication Severity. Mol Pharmacol, 99(1), 17-28. doi:10.1124/molpharm.120.000119
  • AlZaim, I., Hammoud, S. H., Al-Koussa, H., Ghazi, A., Eid, A. H., & El-Yazbi, A. F. (2020). Adipose Tissue Immunomodulation: A Novel Therapeutic Approach in Cardiovascular and Metabolic Diseases. Front Cardiovasc Med, 7, 602088. doi:10.3389/fcvm.2020.602088
  • Wehbe Z, Hammoud S, Soudani N, Zaraket H, El-Yazbi A and Eid AH (2020) Molecular Insights Into SARS COV-2 Interaction With Cardiovascular Disease: Role of RAAS and MAPK Signaling. Front. Pharmacol. 11:836. doi: 10.3389/fphar.2020.00836
  • Hammoud, S. H., Alkhansa, S., Mahjoub, N., Omar, A. G., El-Mas, M. M., & Eid, A. A. (2018). Molecular basis of the counteraction by calcium channel blockers of cyclosporine nephrotoxicity. Am J Physiol Renal Physiol, 315(3), F572-F582. doi:10.1152/ajprenal.00275.2017
  • Hammoud, S. H., Omar, A. G., Eid, A. A., & El-Mas, M. M. (2017). CYP4A/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats. Toxicol Appl Pharmacol, 334, 110-119.
  • Hammoud S. and Ghoneim A. (2016) Pharmacogenetics of Thiazide Diuretics- An Update on Inter-individual Variations. Springer Science Reviews 4

Abstracts:

  • - Hammoud, S.H., Al Zaim., I., Bekdash, A., Itani, H.,A., Mougharbil, N., & El-Yazbi, A., F.(2021) Autonomic Modulation Mitigates Perivascular and Perirenal Adipose Inflammation and Consequent Cardiorenal Involvement in Prediabetes. Circulation, 2021; 144:A9725

    - Al-Saidi A.M., Abdallah, S., Hammoud, S.H., Mougharbil, N., & El-Yazbi, A.F. (2021), Interruption of Perirenal Adipose Tissue Thromboinflammation Reverses Prediabetic Kidney Impairment. Circulation, 2021; 144:A10233

    - Hammoud, S.H., Koubar, S., Mougharbil, N.H., Eid, A.H. & El-Yazbi, A.F. (2020), Peri‐renal Adipose Tissue Inflammation Possibly Underlies Mild Renal Dysfunction in Early Metabolic Challenge. The FASEB Journal, 34: 1-1. doi:10.1096/fasebj.2020.34.s1.05464

    - Hammoud S.H., Mougharbil, N., Eid, A.A., & El-Yazbi A. F., (2019) Metabolic Stress-Induced Renal Endothelial Dysfunction. The FASEB Journal Pages 512.12 512. 12.

    - Hammoud S.H., Omar A.G., Eid. A.A., & El-Mas M.M., (2017) Molecular Mechanisms of the Protective Effects of Calcium Channel Blockers against Cyclosporine Nephrotoxicity in Rats. The FASEB Journal Pages 998.7-998.7.

Activities

Professional Membership:

- Member, American Physiological Society 
- Member, American Society of Pharmacology and Experimental Therapeutics 
- Member, Order of Pharmacists in Lebanon  

Independent reviewer for:
- Bioengineered
- Frontiers in Endocrinology

Teaching certificates and Workshops: 

- Certificate of attendance of an online webinar: Planning and Setup of a Grant Administration Infrastructure,
June 2021, Higher Education Capacity Development Program funded by USAID
- Certificate of attendance of an online webinar: Tips and Strategies on Proposal Development, July 2021,
Higher Education Capacity Development Program funded by USAID
- Certificate of attendance of an online seminar Women’s equity and Empowerment, Nov. 2020, Higher
Education Capacity Development Program funded by USAID
- Certificate of attendance to forum entitled Third forum on advancing pharmacy education in the middle east
and the gulf region, May 2018, Beirut Arab University
- Certificate of attendance of training workshop entitled Teaching Threshold concepts and recognizing cognitive
overload: Evaluating academic practice on our taught programmes, Nov. 2018, Beirut Arab University and
University of Roehampton

Recent conferences attended:

- International Conference of Pharmaceutical and Healthcare Sciences 2019, Alexandria-Egypt
- Experimental Biology, April 2019, Orlando, USA
- 10th annual AUB Biomedical Research Day, March 2019, AUB, Lebanon
- Annual AUB Biomedical Research Day, March 2018, AUB, Lebanon
- Experimental Biology, April 2017, Chicago, USA

Awards

- Paul Dudley White International Scholar Award-2021; The American Heart Association, highest-ranked abstract in the scientific sessions 

- Best Oral Presentation Award - 2019; International Conference of Pharmaceutical and Healthcare Sciences, Alexandria, Egypt 

- Postdoctoral Poster Award - 2019; American Society of Pharmacology and Experimental Therapeutics, Experimental Biology 2019, Orlando, USA

- Predoctoral Research Award - 2015/2016; Lebanese National Council for Scientific Research/ Beirut Arab University (L-CNRS/BAU)