Mahmoud khalil

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Mahmoud khalil

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Biological Sciences

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Mahmoud khalil

Head of Biological Sciences Department and Associate Professor

Associate Professor Mahmoud Khalil completed his PhD at University College London, UK in 2010. In 2012, He worked as a post-doctoral research fellow at Department of Molecular Carcinogenesis, MD Anderson Cancer Center, University of Texas, USA. In 2014, he started his own group at the Molecular Biology Unit, Faculty of Science, Alexandria University, Egypt, where he has an active research group working on signal transduction via the mTOR/S6K pathway in normal and cancer cells. Currently, he is an associate professor at the Department of Biological Sciences, Faculty of Science, Beirut Arab University since 2018. Research themes; Phytochemicals and Carcinogenesis, Cancer Cell Signaling, Epigenetics and the regulation of growth and energy metabolism in normal and cancer cells.


Fall 2018/2019:

  • Developmental Biology
  • Endocrinology
  • Cell and Tissue Culture
  • Mammalian Toxicology
  • Systems Biology


Selected publication

  1. “Developing Spindlin1 Small Molecule Inhibitors Using Protein Microarrays” Narkhyun bae, Monica Viviano, xiaonan su, Jie Lv, Donghang Cheng, Cari Sagum, Sabrina Castellano, Xue Bai, Claire Johnson, Mahmoud I. M. Khalil, Jianjun Shen, KaiFu Chen, Haitao Li, Gianluca Sbardella, Mark T. Bedford. Nature Chemical Biology, 13, 750-756 (2017).
  2. “A Potential Antitumor Activity and Apoptosis induction of Glossostemon Bruguieri Root Extract against HepG2 Hepatocellular Carcinoma Cells” Mahmoud I.M. Kalil, Mohamed Ibrahim, Gehan El-Gaaly, Mona Alwhibi, Ahmed Sultan.; Evidence-Based Complementary and Alternative Medicine Volume (2017), Article ID 7218562, 14 pages.
  3. “Quercetin Induces Apoptosis in Triple-negative Breast Cancer Cells via Inhibiting Fatty Acid Synthase and β-catenin” Ahmed Sultan, Mahmoud I.M. Kalil, Besra Sami, Afrah Alkhuriji, Omayma Sadek. International Journal of Clinical & Experimental Pathology, 10(1):156-172 (2017).
  4. “Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 & Proliferating Cell Nuclear Antigen” Mahmoud I. M. Khalil, M. Ibrahim, G. El-Gaaly, A. Sultan. Biomed Research International. Volume (2015), Article ID 914645, 11 pages.
  5. “Detection of shiga-toxin producing E. coli (STEC) in leafy greens sold at local retail markets in Alexandria, Egypt” Rowaida Khalil, Mohamed Gomaa, Mahmoud I.M. Khalil. International Journal of Food Microbiology. (2015) 197: 58-64.
  6. “S6 Kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo" Ismail, H.; Hurd, P.; Mahmoud I. M. Khalil; Kouzarides, T.; Bannister, A.; Gout, I. Journal of Cellular Biochemistry, 115:1048-1062 (2014).
  7. "Overexpression or Downregulation of mTOR in Mammalian Cell". “mTOR: Methods and Protocols Series”. Mahmoud I. M. Khalil and Gout, I. Book chapter: Methods in Molecular Biology, 821:87-103 (2012).


  • Certified Associate trainer, Training of Trainers (TOT), International Board of Certified Trainers (IBCT).
  • Trainer at Faculty and Leadership Development Center (FLDC), Alexandria University, Egypt.
  • Member of the organizing Committee for 7th Environmental Forum at the Alexandria University: Climate change and sustainable development objectives.


  • Post-doctoral Research Fellowship, MD Anderson Cancer Center, Department of Molecular Carcinogenesis, the University of Texas USA.
  • Ph.D. Scholarship Award offered by the Egyptian government for use in UK.
  • B.Sc. Faculty Award, Alexandria University, for being the first on the department (Distinction First Class Honor) 1997.