Results

Mahmoud khalil

Image Description

Mahmoud khalil


Download CV


Biological Sciences


m.khalil@bau.edu.lb


07 985080 Ex: 3303


Debbieh


Mahmoud khalil

Head of Department of Biological Sciences


Dr. Mahmoud Khalil completed his PhD at University College London, United Kingdom in 2010. In 2012, He worked as a post-doctoral research fellow at Department of Molecular Carcinogenesis, MD Anderson Cancer Center, University of Texas, USA. In 2014, he started his own group at the Molecular Biology Unit, Faculty of Science, Alexandria University, Egypt, where he has an active research group working on signal transduction via the mTOR/S6K pathway in normal and cancer cells. He Joined BAU in 2018. Currently, he is the Chairman of the Department of Biological Sciences, Faculty of Science, Beirut Arab University since 2020. Research themes; phytochemicals and carcinogenesis, cancer Cell Signaling, epigenetics and the regulation of growth and energy metabolism in normal and cancer cells, and synthesis of green nanomaterials and its biomedical applications. He authored around 70 articles published in peer-reviewed journals including Nature Chemical Biology, Life Sciences, Drug Discovery Today, Frontiers in Bioengineering and Biotechnology, and Bioscience Reports.

SELECTED ARTICLES

Health and Wellbeing Theme:

Studying human disorders at the molecular level (subtheme)

  1. [2023] Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function. Int. J. Mol. Sci. 2023, 24(10), 8806. Mahmoud Khalil, Heba M. Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E. Pardo
  2. [2023] Biological Factors Underpinning Suicidal Behaviour: An Update. Brain Sciences. 2023; 13(3):505. Maya Abou Chahla, Mahmoud Khalil, Stefano Comai, Lena Brundin, Sophie Erhardt, Gilles J. Guillemin.
  3. [2023] Proapoptotic and Antiproliferative Effects of the Desert Truffle Terfezia boudieri on Colon Cancer Cell Lines. Evid Based Complement Alternat Med, Volume (2023), Article ID 1693332. Katia Sawaya, Sonia Abou Najem, Ghada Khawaja, Mahmoud Khalil
  4. [2022] Effects of continuous prenatal and postnatal global system for mobile communications electromagnetic waves (GSM-EMW) exposure on the oxidative stress biomarkers in female rat liver. Heliyon 8, no. 12 (2022): e12367. Mariam Salameh, Sukaina Zeitoun-Ghandour, Lina Sabra, Lina Ismail, Ahmad Daher, Ali Bazzi, Mahmoud Khalil, Wissam Joumaa
  5. [2022] Beneficial role of naringin against methotrexate-induced injury to rat testes: biochemical and ultrastructural analyses. Redox Report 27, no. 1 (2022): 158-166. Hany Elsawy, Abdullah M Alzahrani, Manal Alfwuaires, Ashraf M Abdel-Moneim, Mahmoud Khalil
  6. [2022] Insights into COVID-19 Vaccines Development: Translation From Benchside to Bedside. Health Sciences Review, 4:100040. Marwa Houssein, Aya El Asir Al Hossainy, Jana Al soussi, Jana El Batch, Lana El-Samadi, Sherine El Imam, Rawan Fakih, Hoda Dakdouk, Mahmoud Khalil
  7. [2022] Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain. Neurotoxicology and Teratology (2022): 107095. Mohammad H. Merii, Manal M. Fardoun, Khalil El Asmar, Mahmoud Khalil, Ali H. Eid, Hassan R. Dhaini.
  8. [2021] Combination of docosahexaenoic acid and Ginko biloba extract improves cognitive function and hippocampal tissue damages in a mouse model of Alzheimer's disease. Journal of Chemical Neuroanatomy, Volume 116, October 2021, 101995 Nabila Abdelmeguid, Mahmoud Khalil, Rasha Elhabet, Ahmed Sultan, Sherine Abdel Salam
  9. [2021] Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats. Biomedicine & Pharmacotherapy, Volume 143, November 2021, 112180. Hany Elsawy, Abdullah M. Alzahrani, Manal Alfwuaires, Ashraf M. Abdel-Moneim, Mahmoud Khalil.
  10. [2021] Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers. Journal of Chemical Neuroanatomy, Volume 115, September 2021, Hany Elsawy, Abdullah Alzahrani, Manal Alfwuaires, Azza Sedky, Eman El-Trass, Omar Mahmoud, Ashraf Abdel-Moneim, Mahmoud Khalil.
  11. [2020] Apoptosis as a mechanism for treatment of Adult T cell Leukemia: Promising drugs from benchside to bedside. Drug Discovery Today. (2020) 25 (7), 1189-1197. Marwa Houssein, Mahmoud Khalil, Maamoun Fatfat, Hala Gali-Muhtasib
  12. [2020] Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia/lymphoma. Life Sciences. (2020) 251, ID 117639. Marwa Houssein, Maamoun Fatfat, Zeina Habli, Nasab Ghazal, Sara Mokdad, Hala Khalife, Mahmoud Khalil, Hala Gali-Muhtasib.
  13. [2019] Impacts of prolonged chlorpyrifos exposure on locomotion and slow-and fast- twitch skeletal muscles contractility in rats. Toxicology Reports, 6, 598-606 (2019). Nancy Hallal, Hiba Sabbouri, Ali Salami, Wiam Ramadan, Hassan Khachfe, Mohamed Moustafa, Mahmoud Khalil, Wissam Joumaa.
  14. [2017] Developing Spindlin1 Small Molecule Inhibitors Using Protein Microarrays. Narkhyun bae, Monica Viviano, xiaonan su, Jie Lv, Donghang Cheng, Cari Sagum, Sabrina Castellano, Xue Bai, Claire Johnson, Mahmoud Khalil, Jianjun Shen, KaiFu Chen, Haitao Li, Gianluca Sbardella, Mark T. Bedford. Nature Chemical Biology, 13, 750-756 (2017).
  15. [2017] A Potential Antitumor Activity and Apoptosis induction of Glossostemon Bruguieri Root Extract against HepG2 Hepatocellular Carcinoma Cells. Mahmoud Khalil, Mohamed Ibrahim, Gehan El-Gaaly, Mona Alwhibi, Ahmed Sultan.; Evidence-Based Complementary and Alternative Medicine Volume (2017), Article ID 7218562, 14 pages.
  16. [2017] Quercetin Induces Apoptosis in Triple-negative Breast Cancer Cells via Inhibiting Fatty Acid Synthase and β-catenin. Ahmed Sultan, Mahmoud Khalil, Besra Sami, Afrah Alkhuriji, Omayma Sadek. International Journal of Clinical & Experimental Pathology, 10(1):156-172 (2017).
  17. [2015] Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 & Proliferating Cell Nuclear Antigen. Mahmoud Khalil, M. Ibrahim, G. El-Gaaly, A. Sultan. Biomed Research International. Volume (2015), Article ID 914645, 11 pages
  18. [2014] S6 Kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo" Ismail, H.; Hurd, P.; Mahmoud Khalil; Kouzarides, T.; Bannister, A.; Gout, I. Journal of Cellular Biochemistry, 115:1048-1062 (2014).
  19. [2012] Overexpression or Downregulation of mTOR in Mammalian Cell. mTOR: Methods and Protocols Series. Mahmoud Khalil and Gout, I. Book chapter: Methods in Molecular Biology, 821:87-103 (2012).

Industrial and medical microbiology (subtheme)

  1. [2022] Synthesis, Characterization, and Antibacterial Activity of Mg-Doped CuO Nanoparticles. Molecules. 2022 Dec 23;28(1):103. Russul Adnan, Malak Mezher, Alaa Abdallah, Ramadan Awad, Mahmoud Khalil
  2. [2020] Novel Biogenic Silver Nanoparticle-Induced Reactive Oxygen Species Inhibit the Biofilm Formation and Virulence Activities of Methicillin-Resistant Staphylococcus aureus (MRSA) Strain. Frontiers Bioeng & Biotechnology. (2020) Volume 8, Article 433. Reham Hamida, Mohamed Ali, Doaa Goda, Mahmoud Khalil, Mayasar Al-Zaban.
  3. [2015] Detection of shiga-toxin producing E. coli (STEC) in leafy greens sold at local retail markets in Alexandria, Egypt. Rowaida Khalil, Mohamed Gomaa, Mahmoud Khalil. International Journal of Food Microbiology. (2015) 197: 58-64.

Science and Technology Theme:

Environmental studies (subtheme)

  1. [2020] Fluorescence polarization assay to detect the presence of traces of ciprofloxacin. Scientific Reports. (2020) 10 (1), 1-6. Hiyam Kojok, Nada El Darra, Mahmoud Khalil, Alessandro Capo, Angela Pennacchio, Maria Staiano, Alessandra Camarca, Sabato D’Auria, Antonio Varriale.

COURSES TAUGHT

Undergraduate Courses

  • First Level Medical students: Molecular biology; Genetics
  • Second Level Medical students: Recombinant DNA
  • Third Level Medical students: Immunology; Genetics.
  • Pre-Dentistry, Pre-Pharmacy, and First level Science Courses: Physiology; Cytology; Histology; Genetics; Animal Taxonomy; General Biology
  • Second level Science Courses: Cell Biology.
  • Third level Science Courses: Molecular Biology (1); Cell Differentiation & Tissue Culture; Micro-techniques and Cellular Imaging; Practical Molecular Biology;
  • Fourth level Science Courses: Cell & Tissue Culture; Cellular Signal Transduction; Molecular Biology (2); Molecular Neurobiology; Biotechnology; Bioinformatics; Endocrinology; Developmental Biology; Senior Project.

Postgraduate Courses

Advanced Cell Biology; Signal Transduction; Genomics and Proteomics; Systems Biology; Protein Analysis; Molecular Diagnostics; Mammalian Toxicology; Special Topics in Molecular Biology; Animal Cell culture & Tissue Engineering; Biology of RNA; Advanced Proteomics; Research Techniques; and Independent Studies

Projects/Conferences/Activities

  • Certified Associate trainer, Training of Trainers (TOT), International Board of Certified Trainers (IBCT).
  • Trainer at Faculty and Leadership Development Center (FLDC), Alexandria University, Egypt.
  • Member of the organizing Committee for 7th Environmental Forum at the Alexandria University: Climate change and sustainable development objectives.
  • (Mar 2019-Present) Representative and coordinator of BAU at the Lebanese Standards Institution – LIBNOR.
  • (Jan 2018-Present) Associate certified trainer in the International Board of Certified Trainers (IBCT).
  • (June 2017-Present) Lecturer and Trainer at Faculty and Leadership Development Center (FLDC), Alexandria University, EGYPT.
  • (23-24 Apr 2016) Organizing Committee for 7th Environmental Forum: Climate change and sustainable development objectives. Alexandria University, EGYPT.
  • (2009) Organizing the First Annual Conference for the Egyptian Scholars in United Kingdom.
  • (2008-2009) President of the Egyptian Scholars' union in the United Kingdom.
  • (Apr 2002) Training at the Pioneers’ Institute (Ministry of Higher Education, EGYPT).
  • (1997-Present) Member of the General Egyptian Society for the Talented.

[2019–2022] International Post Graduate Studies in Environmental Management and Sustainability for Mediterranean Countries (ENVIPRO-MED). International Project: Montpellier University and Institute of Research for Development (IRD), France. (Collaborator)

[2016–2018] Novel Bacterial Redox Protein Nanofibers Delivery System: A Promising therapeutic Treatment Strategy for Hepatocellular Carcinoma. National Project: STDF project granted the Egyptian government (Principal Investigator)

[2014–2017] Targeting Therapy for Advanced Hepatocellular Carcinoma stem cells by Novel Microarray. National Project: Alex Rep project granted by Alexandria University, Egypt (Co-Principal Investigator)

[2010–2012] Evaluation of the Microbiological Safety of Fresh Produce Leafy Greens and their Potential Contamination with Escherichia coli serotype O157:H7. National Project: Alex Rep project granted by Alexandria University, Egypt (Collaborator)

[2011–2013] Implementing a Scientific International master for biotechnology and neuroscience in the South Mediterranean Area. International Project: Tempus project " granted by the European Commission (Teacher)

Awards

  • Post-doctoral Research Fellowship, MD Anderson Cancer Center, Department of Molecular Carcinogenesis, the University of Texas USA.
  • Ph.D. Scholarship Award offered by the Egyptian government for use in UK.
  • B.Sc. Faculty Award, Alexandria University, for being the first on the department (Distinction First Class Honor).