Science - Course - Physical Organic Chemistry

Determination of reaction mechanism: Kinetic and non-kinetic methods for the elucidation of reaction mechanism: Product analysis, detection or/and isolation of intermediates, isotopic labeling and kinetic isotope effect (KIE), stereochemical evidence, effect of structure and kinetic evidence. Molecular Rearrangement: Neighboring group participation, carbanionic and cationic rearrangement. Structure-activity relationships. Free energy relationships. Quantitative estimation of electronic effects (Hammett and Taft’s equation equations). Frontier Molecular Orbital (Woodward Hoffmann Rule). Electrocyclic reactions. Pre-req.: CHEM 341.