Implanted biomedical devices are witnessing great attention in finding solutions to complex medical conditions. Many challenges face the design of implantable biomedical devices including designing and implanting antennas within hostile environment due to the surrounding tissues of human body. Implanted antennas must be compact in size, efficient, safe, and can effectively work within adequate medical frequency bands. This paper presents an overview of the major aspects related to the design and challenges of in body implanted antennas. The review includes surveying the applications, design methods, challenges, simulation tools, and testing and manufacturing of implantable biomedical antennas.