This study aims to optimize the carbon sequestration, compressive strength, and water transport properties (i.e., water absorption and volume of permeable voids) of concrete masonry blocks incorporating calcium carbide residue (CCR) as a partial cement replacement. The Taguchi design of experiments was utilized to study the influence of CCR replacement percentage, initial air curing duration, carbonation duration, and CO2 gas pressure on the performance responses. These response criteria include CO2 uptake, carbonation depth, compressive strength, water absorption, and volume of permeable voids. The concrete mixture proportions were then optimized for superior performance. The results highlight that a CCR replacement level of 10% was required for optimum carbon sequestration potential, while only 5% was optimum for superior strength and water transport properties. To maximize each performance …