A Novel Multi-Functional Fluorescent Probe for Cu2+, Fe3+ and Ag+ Based on a Pyrimidine Thiourea Derivative


A multi-functional “turn-off” fluorescent probe, N-[[(6-Amino-1,2,3,4-tetrahydro-1,3- dimethyl-2,4-dioxo-5pyrimidinyl)amino]thioxomethyl]- benzamide, was synthesized and characterized. The probe showed high sensitivity and selectivity towards copper(II), iron(III) and silver(I) ions via quenching of its fluorescence. The detection limits were found to be 4.0–16.0 ppb for the assayed cations. The thiourea linked uracil fluorescent probe is proved to be sensitive, selective, and applicable in real samples and promise for practical applications.


El Dakdouki M.H.


Hammoud H.H., Bou Hadir K., Sonji N.M., Sonji G.M.

Journal/Conference Information

Current Analytical Chemistry,DOI: 10.2174/1573411011666150324231041