Introduction Preeclampsia is characterized by hypertension and proteinuria in preg-nant woman. Angiotensin converting enzyme (ACE) is involved in the conversion of angiotensin I into angiotensin II which is a vasoconstrictive molecule that affects sys-temic blood pressure. ACE gene is highly polymorphic and the most common studied polymorphism is the presence (insertion, I) or absence (deletion, D) of a 287 base pair fragment of Alu sequence of DNA in intron 16 of the gene. Several studies have shown that the DD genotype in ACE is associated with a higher prevalence of preeclampsia in some population. Objective This study investigated whether there is an association between ACE inser-tion/deletion (I/D) polymorphism and the risk of preeclampsia in the Lebanese popula-tion. Materials and Methods In this study, 30 preeclamptic and 32 normotensive Lebanese pregnant women were genotyped for ACE I/D polymorphism. DNA was isolated from peripheral leukocytes and amplified by PCR. Then, the size of PCR products was iden-tified by agarose gel electrophoresis. Results The DD genotype was found in 46.7% of preeclamptic patients while the ID genotype was 36.7% and the II genotype was 16.7%. The genotypes of ACE in control subjects were 40.6% DD, 37.5% ID and 21.9% II. Statistical analysis showed that there was no significant difference in ACE genotype between preeclampsia and control sub-jects. Conclusion There is no association between ACE I/D polymorphism and preeclampsia in woman in the Lebanese population.