Thesis & Dissertations

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of memory and the ability to learn and comprehend. Regrettably, AD remains a mystery and finding effective therapies revealed to be a discouraging task. The aggregates of β-amyloid are considered one of the most prominent pathological signs of the disease. Thus, much effort towards the detection of the disease is directed towards the development of biomarkers that selectively bind to β-amyloid aggregates. The most successful biomarker that caught much attention and is undergoing extensive clinical trials is Pittsburgh compound [11C]- PiB, 1a. We become interested in the development of substituted 2H-indazoles under the Davis-Beirut reaction conditions. The structural resemblance between the synthesized indazoles and [11C]-PiB prompted us to propose the synthesis of a novel series of 2H-indazole analogues as potential binders of β-amyloid plaques.