Pharmacology

Description of Subtheme:

Most studies done in Pharmacology and Therapeutics Department are pertinent with discovering the molecular mechanisms of drugs used in the management of the most commonly encountered organ disorders and diseases in order to optimize pharmacotherapy spatially for patients with chronic disease. In this context, the elucidation and the characterization of the molecular mechanisms underlying the beneficial and/or detrimental effects of such drugs are preclinical investigated using pharmacological and biochemical techniques. Research was also done to test newly synthesized compounds and old molecules for their anti-inflammatory and analgesic effects. The molecular mechanistic effect of the potential molecules was also investigated using different procedures. As an example, the role of substitution on amide-linked bi-pyrazoles was assessed based on the known anti-inflammatory effect of the pyrazole compounds. Tadalafil, a known molecule used to treat erectile dysfunction, was investigated for its antinociceptive effect in various inflammatory pain models. Tacrine derivatives known to be used for Alzheimer’s disease were investigated for their anti-inflammatory properties. Research was also done to test newly synthesized compounds and old molecules for their anti-inflammatory and analgesic effects. The molecular mechanistic effect of the potential molecules was also investigated using different procedures. As an example, the role of substitution on amide-linked bi-pyrazoles was assessed based on the known anti-inflammatory effect of the pyrazole compounds. Tadalafil, a known molecule used to treat erectile dysfunction, was investigated for its antinociceptive effect in various inflammatory pain models. Tacrine derivatives known to be used for Alzheimer’s disease were investigated for their anti-inflammatory properties.

Research Action Plan:

• Investigating possible mechanisms within the body and their effects on various physiological systems
• Investigating the molecular mechanisms underlying drug effects on major body function

Prominent Research:

• • Domiati S., Mehanna M., Ragab H., Nakkash-Chmaisse H., El Mallah A. (2018). Investigation of chronic efficacy and safety profile of two potential anti-inflammatory bipyrazole-based compounds in experimental animals. Journal of Inflammation Research, 11:143-153.
  • Mehanna, M. M., Domiati, S., Nakkash Chmaisse, H., & El Mallah, A. (2018). Antinociceptive effect of tadalafil in various pain models: Involvement of opioid receptors and nitric oxide cyclic GMP pathway. Toxicology and applied pharmacology, 352, 170–175. https://doi.org/10.1016/j.taap.2018.05.013
  • Domiati, S., Mehanna, M., Ragab, H., El Galil, K. H. A., Nakkash-Chmaisse, H., & El Mallah, A. (2019). Elucidation of the molecular mechanism underlying the anti-inflammatory activity of an effective and safe bipyrazole-based compound. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 68(5), 379–386. https://doi.org/10.1007/s00011-019-01225-z
  • Mehanna, M., Domiati, S., Nakkash Chmaisse, H., & El Mallah, A. (2020). Analgesia additive interaction between tadalafil and morphine in an experimental animal model. Canadian journal of physiology and pharmacology, 98(11), 771–776. https://doi.org/10.1139/cjpp-2019-0674
  • Domiati, S. A., Abd El Galil, K. H., Abourehab, M. A. S., Ibrahim, T. M., & Ragab, H. M. (2022). Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity. Journal of enzyme inhibition and medicinal chemistry, 37(1), 2179–2190. https://doi.org/10.1080/14756366.2022.2109025
  • Domiati, S., Abd El Galil, K., & Ragab, H. (2022). Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators. ACS omega, 7(48), 43747–43758. https://doi.org/10.1021/acsomega.2c04761