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Pharmaceutical Analytical Chemistry

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Analytical chemistry holds a pivotal position in the development and assurance of pharmaceutical product safety, effectiveness, and quality. This directly influences the availability of vital medicines, a central goal within SDG 3. Furthermore, in alignment with Responsible Consumption and Production (SDG 12), pharmaceutical analytical research advocates for sustainable approaches in drug manufacturing. This includes waste reduction, efficient resource management, and adoption of eco-friendly production techniques, all of which foster responsible consumption and production practices

Science and Technology

Description of Subtheme:

Our researchers in Drug Quality Control are at the forefront of investigating the latest advancements in analytical techniques, primarily focusing on drug quality control, purity, and stability assessment. Their work entails the constant pursuit of cutting-edge methods and technologies to ensure the efficacy and safety of pharmaceuticals. Additionally, the researchers are actively engaged in the development and utilization of environmentally friendly, "green" analytical approaches. These sustainable methods are employed to evaluate medications in various dosage forms, contributing to a more ecologically responsible pharmaceutical industry.

They are developing new analytical methodologies or modifying methods to incorporate procedures that use less hazardous chemicals. The main goal in Quality Control laboratories is to achieve more eco-friendly methods through different strategies and techniques, replace toxic reagents, and modify or replace analytical methods and/or techniques with safer ones, making it possible to reduce the amounts of reagents consumed and waste generated. The most important challenge to the future of this discipline is to reach a compromise between the increasing quality of the results and the improving environmental friendliness.

Relevant Research Interest

  • Investigating the new advancements in analytical techniques for drug quality control, purity, and stability assessment
  • Manipulating green analytical methods in the evaluation of medications in different dosage forms

Prominent Research:

  • Validated ion exchange HPLC method for the quantification of levothyroxine – a narrow therapeutic index drug – used for the treatment of hypothyroidism

Marwa Al Jamal, Malak Al Bathish and Azza Gazy, Pharmacia 70(2): 299–305(2023) DOI 10.3897/pharmacia.70. e103242

  • Analysis of Closely Related Antioxidant Nutraceuticals Using the Green Analytical Methodology of ANN and Smart Spectrophotometric Method” Mohamed A. Korany ,Azza A. Gazy ,EssamF. Khamis and Marwa A.A. Ragab and Miranda F. Kamal ,Journal of AOAC International Vol. 100, No. 1, 2017

DOI: 10.5740/jaoacint.16-0203

  • Least median of squares and iteratively re‐weighted least squares as robust linear regression methods for fluorimetric determination of α‐lipoic acid in capsules in ideal and non‐ideal cases of linearity

Mohamed A. Korany, Azza A. Gazy, Essam F. Khamis , Marwa A. A. Ragab and

Miranda F. Kamal,  Luminescence.  2018; 33:742–750.

DOI: 10.1002/bio.3471

  • Development and validation of analytical spectrophotometric and RP-HPLC methods for the simultaneous estimation of hydroquinone, hydrocortisone and tretinoin ternary mixture in topical formulation

Marwa K. El Jamal, Azza A. Gazy ,IJPPS 11(11):10-16, (2019).

  • RP-HPLC and Chemometric Methods for The Determination of Two Anti-Diabetic Mixtures; Metformin Hydrochloride-Canagliflozin and Metformin Hydrochloride-Gliclazide in Their Pharmaceutical Formulation

Malak Y. Al Bathish , Azza A. Gazy , Marwa K. El Jamal,IJPPS 12(3), (2020).

  • Identification and Quantification of Phosphodiesterase-5 inhibitors as Adulterants in Dietary Supplements Marked for Sexual Enhancement in the

Lebanese Market

Razan soubra, Azza A. Gazy, May Saab, Marwa K. Al Jamal, IJPPS 12(2), (2020).

  • In Vitro Equivalence Study of Generic Metformin Hydrochloride Tablets under Biowaiver Conditions

Ruaa H. AL Arwadi, Azza A. K. Gazy, Lama Soubra, Rola D. Ajami, Health and wellbeing,2(2),(2020)